Effect of vaccination of goats with H-gal-GP and H11 antigens from intestinal membrane cells of Haemonchus contortus
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Assessment of Caenorhabditis elegans as a model in Haemonchus contortus vaccine research.
Over the past decade Caenorhabditis elegans has become popular model organism for parasitic nematode research and any examples have been published to illustrate its use [1]. t has especially been useful for the research on mechanisms f action of anthelmintics and on anthelmintic resistance [2]. owever, its validity in parasite vaccine research is less clear. It as been suggested that studying g...
متن کاملExpression of Caenorhabditis elegans-expressed Trans-HPS, partial aminopeptidase H11 from Haemonchus contortus.
Aminopeptidase H11 present in the surface of intestine microvilli in Haemonchus contortus was identified as the most effective antigen candidate. However, its recombinant forms produced in Escherichiacoli, insect cells and yeast could not provide promising protection against H. contortus challenge, probably due to the inappropriate glycosylation and/or conformational folding. Herein, partial H1...
متن کاملProteomic Analysis of Mecistocirrus digitatus and Haemonchus contortus Intestinal Protein Extracts and Subsequent Efficacy Testing in a Vaccine Trial
BACKGROUND Gastrointestinal nematode infections, such as Haemonchus contortus and Mecistocirrus digitatus, are ranked in the top twenty diseases affecting small-holder farmers' livestock, yet research into M. digitatus, which infects cattle and buffalo in Asia is limited. Intestine-derived native protein vaccines are effective against Haemonchus, yet the protective efficacy of intestine-derived...
متن کاملDescription of Haemonchus placei (Place, 1893) (Nematoda, Trichostrongylidae, Haemonchinae), identification and intra-specific morphologic variability.
Haemonchus placei in cattle has never been completely described, possibly due to great morphological similarity with small ruminants Haemonchus contortus. It is newly described on one isolate from Argentina. It has clear distinct morphological features from sheep and goats Haemonchus contortus and presents only two female morphotypes (linguiform and knobbed) instead of three recorded in H. cont...
متن کاملImmunization of Arabian sheep with whole gut homogenate of Haemonchus contortus
Ten female lambs of 7-month-old were divided into two equal groups and raised under a helminth-free conditions. Animals in group 1 were immunized two times by whole gut homogenate (WGH) of Haemonchus contortus emulsified in Freund’s adjuvant. In group 2 (control), animals were injected by phosphate buffered saline emulsified in the same adjuvant. Animals were challenged by 10000 third-stage lar...
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تاریخ انتشار 2017